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Axonal Injury in Early Multiple Sclerosis is Irreversible and Independent of the Short-Term Disease Evolution Neurol 65:1626-1630, Rovaris,M.,et al, 2005 See this aricle in Pubmed Article Abstract Irreversible brain damage associated with axonal dysfunction occurs at a very early stage in patients with clinically isolated syndromes, but it does not seem to be related with the disease evolution in the subsequent short-term period.

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